A 63 year old man had increasing irritability over 3 years. he spent - ProProfs
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A 63-year-old man had increasing irritability over 3 years. He spent a lot of time wandering about his neighborhood, complaining to the neighbors about everything. He had no memory loss and was always able to find his way home. The neighbors were pleased when he developed aphasia. On physical examination, there were no motor or sensory deficits and no gait disturbances or tremor. MRI of the brain showed bilateral marked temporal and frontal lobe gyral atrophy. He died of pneumonia 1 year later. At autopsy, the frontal cortex microscopically shows extensive neuronal loss, and some remaining neurons show intracytoplasmic, faintly eosinophilic, rounded inclusions that stain immunohistochemically for tau protein. What is the most likely diagnosis?



A. Alzheimer disease
B. Huntington disease
C. Leigh disease
D. Multiple system atrophy
E. Parkinson disease
F. Pick disease
G. Vascular dementia
Asked by Luca on Sep 09, 2016

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Pathology Review ch 28 CNS prt 3

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John Smith

John Smith

Answered on Sep 09, 2016

Pick disease-(f) pick disease has clinical features similar to the features of alzheimer disease, but initially it causes less memory loss and more behavioral changes. the knifelike gyral atrophy of frontal and temporal lobes and relative sparing of parietal and occipital lobes are characteristic of pick disease. pick bodies are seen in remaining neurons, but the neuritic plaques and neurofibrillary tangles seen in alzheimer disease are not increased. huntington disease affects mainly the caudate nuclei and basal ganglia; onset occurs in middle age, and choreiform movements are common. leigh disease is a mitochondrial encephalomyopathy that can cause muscular weakness and neurologic deterioration beginning at a young age. multiple system atrophy (msa) has features that overlap those of striatonigral degeneration, olivopontocerebellar atrophy, and shy-drager syndrome; most patients with msa exhibit symptoms similar to those of parkinson disease. msa is characterized microscopically by the appearance of glial cytoplasmic inclusions. in parkinson disease, loss of pigmented neurons in the substantia nigra leads to movement problems. vascular dementia, or multi-infarct dementia, can have clinical features that mimic those of alzheimer disease, but there are multiple small infarcts that collectively produce dementia, and the neurologic decline occurs in a stepwise fashion. bp7 843844bp8 891pbd7 1390pbd8 1318
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