A study is conducted to identify causes of neuronal loss in patients - ProProfs
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A study is conducted to identify causes of neuronal loss in patients 18 to 90 years old who died in the hospital from a natural manner of death and who had autopsies performed. Histologic sections are taken from multiple areas of the brain in each patient. The sections are analyzed for the appearance of red, shrunken neurons, decreased numbers of neurons, or absent neurons. A subset of patients is identified in which the hippocampal pyramidal cells, the cerebellar Purkinje cells, and the superior parasagittal neocortical pyramidal cells are affected. The medical records of these patients are reviewed to determine what risk factors for neuronal loss were present before death. What condition is most likely to be the major cause of neuronal loss in this subset of patients?



A. Autoimmunity
B. Chemotherapy
C. Diabetes mellitus
D. HIV infection
E. Global hypoxia
F. Lead ingestion
G. Poor nutrition
Asked by Chloe on Sep 09, 2016

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Global hypoxia-(e) the neurons that are most sensitive to anoxia reside in the hippocampus, along with the purkinje cells and thelarger neocortical neurons. in addition, the first areas in the neocortex to be affected are the watershed areas betweenthe three major cerebral circulations, including the watershed located superiorly between the anterior cerebral and middlecerebral circulations, as in this study. red shrunken neurons, especially in the areas mentioned, are typically seen in theearly stages of global hypoxia, as may occur in a severe hypotensive episode. focal hypoxia leads to infarcts.autoimmunity can lead to vasculitis and subsequent hypoxemia. chemotherapy tends to damage actively dividing cellsmore severely. diabetes mellitus causes atherosclerosis, which can lead to hypoxemia. hiv infection can produce anencephalitis, and there can be opportunistic infections of the cns. lead poisoning leads to encephalopathy, not ischemia.poor nutrition with a deficiency of thiamine (vitamin b1) can lead to wernicke disease, which affects the mamillary bodiesand periaqueductal gray matter most severely.bp7 813814bp8 863865pbd7 13501351pbd8 12911292
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