A neonate is born prematurely at 28 weeks gestation to a 22 year old - ProProfs Discuss
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A neonate is born prematurely at 28 weeks gestation to a 22-year-old primigravida. The infant is initially stable, and a newborn physical examination shows no abnormalities. The infant becomes severely hypoxemic 24 hours later, and seizure aCTivity is observed. There is poor neurologic development during infancy. CT scan of the head shows symmetrically enlarged cerebral ventricles at 8 months of age. Which of the following perinatal complications most likely produced these findings?



A. Germinal matrix hemorrhage
B. Down syndrome
C. Kernicterus
D. Congenital cytomegalovirus infection
E. Medulloblastoma
Asked by Lewis on Sep 09, 2016

This question is part of

Pathology Review ch 28 CNS prt 3

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Germinal matrix hemorrhage-(a) germinal matrix hemorrhage is the most common cause of intraventricular hemorrhage in premature infants. the germinal matrix, composed of highly vascularized tissue with primitive cells, is most prominent between 22 and 30 weeks of gestation. hemorrhages within this area readily occur with common neonatal problems such as hypoxemia, hypercarbia, acidosis, and changes in blood pressure. hemorrhages in the germinal matrix can extend into the cerebral ventricles and from there into the subarachnoid space. smaller hemorrhages can resolve without sequelae. with larger hemorrhages, organization of the blood in the aqueduct of sylvius or the fourth ventricle or foramina of luschka may obstruct the flow of csf, producing hydrocephalus. infants with down syndrome may have vascular malformations that can bleed into the parenchyma. the bilirubin staining of kernicterus does not result in scarring. cytomegalovirus infection can cause considerable necrosis of the brain parenchyma, but not hemorrhage. medulloblastomas are tumors that occur in children (not typically in infants) that could cause obstruction of csf flow. bp7 824bp8 873pbd7 1356pbd8 1286
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