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A 55-year-old man who had been healthy all his life now has progressive, symmetric muscular weakness. Two years ago, he noted weakness in the area of the head and neck, which caused difficulty with speech, eye movements, and swallowing. In the past year, the weakness in the upper and lower extremities has increased, and he can no longer stand, walk, or feed himself. His mental function remains intact. What is the most likely diagnosis?



A. Amyotrophic lateral sclerosis
B. Huntington disease
C. Multiple sclerosis
D. Guillain-Barré syndrome
E. Parkinson disease

This question is part of

Pathology Review ch 28 CNS prt 3
Asked by G.Beasley, Last updated: Apr 29, 2020

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1 Answer

John Smith

John Smith

Answered Sep 09, 2016

Amyotrophic lateral sclerosis-(a) the progressive and symmetric nature of this patients disease is a classic feature of amyotrophic lateral sclerosis (als). the muscles show a denervation type of grouped atrophy from loss of upper motor neurons. the bulbar form of als affects mainly cranial nerve nuclei and has a more aggressive course. huntington disease causes abnormal movements, not weakness, and there can be associated dementia over time. mental function is preserved in als. the demyelinating plaques of multiple sclerosis can produce various motor signs and symptoms over time, but symmetry is not a feature of this disease. guillain-barrďż˝ syndrome usually occurs after a viral infection and manifests as a rapidly progressive ascending motor weakness. parkinson disease is characterized by rigidity and involuntary movements, not by muscular weakness. bp7 846bp8 896pbd7 13961397pbd8 13241325
 

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