What would most likely be present in the specimens in the finding of the following case?
A 26-year-old woman visits her physician with complaints of vaginal bleeding after sexual intercourse. She started menses at age 14 years and has 32-day cycles. She acknowledges having unprotected sex with multiple partners. Cytologic specimens are taken from the cervix and vagina. On microscopy, cervical cells have large nuclei with open chromatin; several cells have mitotic figures. What would most likely be present in the specimens that account for these findings?
A. Double-stranded DNA virus B. Gram-negative diplococci C. Gram-positive cocci D. Single-stranded RNA E. Squamous cells covered with bacteria
Double-stranded dna virus-the correct answer is a. the fi ndings on microscopy indicate a malignant transformation of normal cells. increased nuclear-to-cytoplasm ratio, open chromatin, and mitotic figures indicate that cells are actively dividing. given the patients history of multiple sexual partners and postcoital bleeding, these cells likely indicate the presence of cervical cancer. cervical cancer is commonly linked to human papillomavirus infection. the virus can be isolated during cytology through various methods. it is a double-stranded dna virus.
answer b is incorrect. gram-negative diplococci are not associated with cervical cancer.
however, they can be found in gonorrhea cervicitis.
answer c is incorrect. there are no gram positive cocci associated with cervical cancer.
answer d is incorrect. there is no singlestranded virus associated with cervical cancer.
answer e is incorrect. squamous cells covered with bacteria can be found in bacterial vaginosis,
which causes foul-smelling discharge. there is no known association between bacterial vaginosis
and cervical cancer.