What is true about Pancoast's Syndrome? - ProProfs Discuss
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What is true about Pancoast's Syndrome?



A. Specifically relates to a complication of small cell carcinoma
B. Is the result of tumor production of ACTH
C. Is often found in association with a pneumoconiosis
D. Is the result of thoracic inlet infiltration by tumor
E. Is the result of lung tumor metastases to the brain
Asked by Jack, Last updated: Aug 01, 2020

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John Smith

John Smith

Answered Sep 09, 2016

Is the result of tumor production of acth-2. is the result of thoracic inlet infiltration by tumor-pancoast syndrome is characterized by a malignant neoplasm of the superior sulcus of the lung with destructive lesions of the thoracic inlet and involvement of the brachial plexus and cervical sympathetic nerves (stellate ganglion).[1, 2, 3] this is accompanied by the following: severe pain in the shoulder region radiating toward the axilla and scapula along the ulnar aspect of the muscles of the hand atrophy of hand and arm muscles horner syndrome (ptosis, miosis, hemianhidrosis, enophthalmos) compression of the blood vessels with edemamost pancoast tumors are squamous cell carcinomas (sccs) or adenocarcinomas; only 3-5% are small cell carcinomas. squamous cell carcinoma occurs more frequently, although large cell and undifferentiated types are also common. adenocarcinoma is sometimes found in this location and can even be metastatic. involvement of the phrenic or recurrent laryngeal nerve or superior vena cava obstruction is not representative of the classic pancoast tumor.a pancoast tumour is an apical tumour that is typically found in conjunction with a smoking history. the clinical signs and symptoms can be confused with neurovascular compromise at the level of the superior thoracic aperture. the patients smoking history, rapid onset of clinical signs and symptoms and pleuritic pain can suggest an apical tumour. a pancoast tumor can give rise to both pancoast syndrome and horners syndrome. when the brachial plexus roots are involved it will produce pancoast syndrome; involvement of sympathetic fibres as they exit the cord at t1 and ascend to the superior cervical ganglion will produce horners syndrome.
 

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