A 52 year old man was admitted to the hospital with an asthmatic - ProProfs
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A 52-year-old man was admitted to the hospital with an asthmatic attack. The man had been suffering from seasonal asthma for one year. On questioning he mentioned that he took two tablets of aspirin for a headache the previous evening. An appropriate therapy was instituted, and he was discharged from the hospital. Which of the following drugs was most likely included in his post discharge therapy?



A. Oral zafirlukast
B. Oral triamcinolone
C. Inhaled ipratropium
D. Oral theophylline
Asked by Luca on Sep 09, 2016

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1 Answer

John Smith

John Smith

Answered on Sep 09, 2016

Oral zafirlukast -zafirlukast (accolate�) chemistry o cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1h-indol-5-ylcarbamate pharmacokinetics o oral administration (on an empty stomach) bioavailability reduced ~40% with food o wide distribution o undergoes extensive hepatic metabolism o excreted primarily in the feces pharmacodynamics o mechanism of action antagonist of cyslt1 (see figure 18) o pharmacological actions/effects blocks lt-mediated effects correlated with asthma airway edema, smooth muscle contraction, pro-inflammatory cellular activity clinical pharmacology o clinical uses prophylaxis and chronic treatment of asthma in adults and children 5 years of age reduction of aspirin-induced asthma in aspirin-sensitive patients o adverse effects/toxicity serious reactions hepatitis, hepatic failure (potentially fatal), churg-strauss syndrome, eosinophilia, vasculitis, hypersensitivity reaction, angioedema, depression common reactions headache, infection, nausea, diarrhea, abdominal pain, alt/ast elevation, insomnia o contraindications acute asthma attack, hepatic impairment pregnancy/lactationcategory b/strong precaution (possibly unsafe)
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