What histologic findings you should expect to see in the biopsy of - ProProfs
     

What histologic findings you should expect to see in the biopsy of the patient in the following case?
A 57-year-old woman with unilateral headache, vision loss and "morning joint stiffness" has a biopsy of her temporal artery done in your office.  What are the histologic findings you would expect to see in the biopsy?



A. Large vessel giant cell vasculitis with fragmentation of elastic lamina
B. Small vessel eosinophilic vasculitis
C. Medium vessel vasculitis with fibrinoid necrosis
D. Large vessel granulomatous vasculitis with massive intimal fibrosis
E. Medium vessel transmural vasculitis

This question is part of

Block 11 - Week 12 - Vasculitis

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3 Answers

C. Wasek

Love to do some charity work. Have a passion for writing and do it in my spare time

C. Wasek, Philanthropist, Post Graduate, Corpus Christi

Answered on Jan 31, 2019

The answer to this question is letter A. This is also known as a condition called temporal arteritis. This is a condition wherein the temporal arteries that are in charge of providing the blood supply to the brain and the head becomes damaged. There are some who do not have damaged arteries but the arteries are inflamed due to various possible reasons.

Do remember that this is a type of condition that may be connected to a lot of other conditions which means that without proper treatment, it can start to become serious after some time. If this is detected early, there are some treatments that can be done in order to stabilize one’s condition.

mssawaf

Mssawaf

Answered on Jun 27, 2017

large vessel giant cell vasculitis with fragmentation of elastic lamina-giant cell teporal arteritis

John Smith

John Smith

Answered on Sep 09, 2016

1. large vessel giant cell vasculitis with fragmentation of elastic lamina-giant cell (temporal) arteritis: histology: granulomatous inflammation media and intima multinucleated giant cells necrosis and fragmentation of the internal elastic membrane later stage: intimal thickening and medial fibrosis clinical manifestations superficial temporal artery is thickened, swollen and tender unilateral headache ipsilateral visual loss polymyalgia rheumatica (pain and morning stiffness in the neck, shoulders, and hips) fever, malaise diagnosed by temporal artery biopsy treat with anti-inflammatory drugs (corticosteroids) prognosis is good subsides in 6 to 12 months if left untreated blindness akayasu arteritis: granulomatous inflammation with [[ massive intimal fibrosis ]] aortic arch and its major branches gross appearance irregular thickening (intimal fibrosis) of the vascular wall intimal wrinkling narrowing of the orifices of major arterial branches (carotid, subclavian) microscopic appearance giant cell granulomas transmural mononuclear inflammation later changes: [[ fibrosis and intimal proliferation ]]

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