A 50-year-old man has a 2-year history of angina pectoris that occurs during exercise. On physical examination, his
blood pressure is 135/75 mm Hg, and his heart rate is 79/min and slightly irregular. Coronary angiography shows a fixed
75% narrowing of the anterior descending branch of the left coronary artery. Which of the following types of cells is the
initial target in the pathogenesis of this arterial lesion?
A. Monocytes B. Smooth muscle cells C. Platelets D. Neutrophils E. Endothelial cells
Endothelial cells-atherogenesis can be considered a chronic inflammatory response of the arterial wall to endothelial injury. the injury promotes participation by monocytes, macrophages, and t lymphocytes. smooth muscle cells are stimulated toproliferate. platelets adhere to areas of endothelial injury. neutrophils are not a part of atherogenesis, although they canbe seen in various forms of vasculitis. the process begins with endothelial cell alteration.bp7 334335bp8 342, 346348pbd7 521523pbd8 499500