Which of the following peripheral blood cells will decrease first in this patient?
A 45-year-old man recently diagnosed with small cell lung cancer starts his first course of combination chemotherapy with cisplatin, topotecan, and etoposide.
A. Lymphocytes B. Platelets C. Monocytes D. Granulocytes E. Erythrocytes
The irregular cellular immune function has been exhibited in patients with lung cancer, and they also have decreased numbers of circulating lymphocytes. Lymphocytes play an integral part in the body's immune system. It is a type of white blood cell, which is responsible for generating a response to foreign invaders of the body.
With a reduced lymphocyte count, the body cannot put up much of a fight, and symptoms can get worse. Small lung cancer tends to spread and grow at a faster rate than non-small cell cancer. Even though chemotherapy helps many people, small cell cancer is a less curable disease than other types.
The correct answer to this question is D, Granulocytes. The number of peripheral blood cells that decrease after chemotherapy cancer treatment will depend on the lifespan of all cellines. When it comes to granulocytes, the life span can be about 4-5 hours in the blood.
It then can spend another 4-5 days in the tissue. Platelets survive for about 10 days. With this information, we can know that the myelosuppression first occurs in the granulocytopenia and then the thrombocytopenia. This makes the other answers correct. For instance, Answer A, lymphocytes can circulate the body for weeks, months, or years,
Granulocytes-answer: dthe decrease of peripheral blood cells after cancer chemotherapy depends upon the life span of that cellline. the life span of granulocytes, once released from the bone marrow, is 4-5 hours in the blood andanother 4-5 days in the tissues. platelets survive about 10 days. therefore myelosuppression first resultsin granulocytopenia followed by thrombocytopeniaa) lymphocytes continually circulate throughout the body and have life spans of weeks, months or evenyears.b) (see explanation above)c) monocytes, once in the tissues, become macrophages and can live for months or even years.e) erythrocytes have a life span of about 120 days