Which of the following statement best explains the mechanism of action of dactinomycin?
A 3-year-old boy diagnosed with a favorable histology Wilms’ tumor underwent surgery followed by 18 weeks of vincristine and dactinomycin therapy.
A. It alkylates nucleophilic groups on RNA bases B. It inhibits dihydrofolate reductase C. It inhibits pyrimidine biosynthesis D. It binds to double-stranded DNA so inhibiting DNA transcription E. It inhibits free radical formation
It binds to double-stranded dna so inhibiting dna transcription-answer: ddactinomycin is a cytotoxic antibiotic. its main mechanism of anticancer action involves binding todouble-helical dna so preventing dna transcription and rna synthesis. dactinomycin is used mainly inwilms tumor, a kidney tumor that is the most common intra-abdominal tumor of childhood and accountsof about 6% of all childhood malignancies.a) this is the mechanism of action of alkylating drugsb) this is the mechanism of action of methotrexatec) this is the mechanism of action of pyrimidine analogse) the formation, not the inhibition, of free radical is one of the postulated mechanisms of action ofsome anticancer drugs including doxorubicin and bleomycin.