Which of the following drugs was most likely given to the client?
A 34-year-old woman with AIDS was found to have a CD4 lymphocyte count of 45
cell/mm at the last control visit. The patient had an extensive hi 3 story of treatment with a
variety of antiretroviral drugs and had been currently taking zidovudine, lamivudine and
ritonavir. A tropism test showed that the HIV of the patient used the CCR5 receptor to
enter the host cells. A therapy with a drug that prevents entry was started.
A. Ribavirin B. Enfuvirtide C. Didanosine D. Maraviroc E. Indinavir F. Saquinavir
Maraviroc-learning objective: explain the mechanism of action of maraviroc.answer: dmaraviroc binds to a specific ccr5 receptor on the viral envelope and blocks the fusion of viraland cellular membrane so preventing viral entry. it has been shown that about 50% of patientsin whom at least two antiviral regimens had failed were infected with r5 hiv-1. since maravirocis active against hiv that use ccr5 exclusively, but not against other hiv strains, tropismtesting should be performed before starting a treatment with this drug, like in the present case.a) ribavirin is not an antiretroviral agent.b) enfuvirtide is an entry inhibitor, but target a gp41 subunit of the viral envelope.c) didanosine is a reverse transcriptase inhibitor.e, f) indinavir and saquinavir are protease inhibitors.
Maraviroc-learning objective: explain the mechanism of action of maraviroc.answer: dmaraviroc binds to a specific ccr5 receptor on the viral envelope and blocks the fusion of viraland cellular...Read More