Which of the following statements best explains the mechanism of the antipyretic effect of the drug in the patient?
The mother of a 17-month-old girl called the pediatrician because she found that the rectal temperature of her daughter was 39.5 CÂ° (103.1 FÂ°). After a physical examination, the pediatrician said that the fever was most likely due to a viral infection and prescribed ibuprofen, oral drops.
A. Binding of the drug to prostaglandin receptors in the hypothalamus B. Inhibition of phospholipase A2 in the hypothalamus C. Inhibition of release of interleukin-1 from tissue macrophages D. Decreased concentration of prostaglandins in the hypothalamus E. Inhibition of cyclooxygenase in peripheral tissues
Decreased concentration of prostaglandins in the hypothalamus-ibuprofen is a non-steroidal antiinflammatory drug (nsaid) of the propionic acid derivativeclass. all nsaids inhibit prostaglandin biosynthesis by blocking cyclooxygenase both in theperipheral tissues and in the cns. the release of prostaglandins (pge1, pge2) in thehypothalamus seems the ultimate factor which adjusts the hypothalamic thermoregulatorymechanism to maintain body temperature at higher than normal level. by inhibitingprostaglandin synthesis nsaids promote the return of the hypothalamic thermostat to thenormal set point.a, b, c) all these action can lead to an antipyretic effect but nsaids do not have theseactions.e) the inhibition of cyclooxygenase in peripheral tissues can lead to an antiinflammatory effectwhich can reduce fever. however the main mechanism of the antipyretic effect of nsaids iscentral rather than peripheral.