Which of the following statements best explains the reason for the low renal clearance of that drug?
The pharmacokinetics of a new drug was studied in a young healthy volunteer. The following data were obtained:
1. The volume of distribution: 347 L
2. Oral bioavailability: 10%
3. Metabolism by the liver: 80%
4. Renal clearance: 5 mL/min.
A. The drug is mainly eliminated by the liver B. The drug is extensively reabsorbed by the renal tubule C. The drug is actively secreted by the renal tubule D. The drug is filtered very slowly by the glomerulus E. The drug has a very low oral bioavailability F. The drug has a large volume of distribution
The drug is extensively reabsorbed by the renal tubule-13) learning objective: explain the reasons of a low renal clearance of a drug.answer: bin a healthy person (i.e. a person with a normal gfr) the only reason why the renal clearance ofa drug is low is because the drug is extensively reabsorbed by the renal tubule.a) yes the drug is mainly eliminated by the liver but this is not the reason of a low renalclearance, since there is no information about the total clearance.c) in this case the renal clearance of the drug should be high.d) the gfr is normal in a young healthy person.e, f) bioavailability and volume of distribution have nothing to do with renal clearance.