Which of the following events most likely caused the patient’s symptoms and signs?
A 35-year-old Caucasian man complained of tingling sensation in his limbs and that his ARMS sometimes felt heavy. The man, recently diagnosed with pulmonary tuberculosis, had been receiving isoniazid and rifampin for 2 months. He was diagnosed with peripheral neuropathy, a known adverse effect of isoniazid.
A. Rifampin-induced inhibition of isoniazid metabolism B. Worsening of the disease, in spite of the therapy C. Allergic reaction to rifampin D. Inherited deficiency of N-acetyltransferase E. Allergic reaction to isoniazid
Inherited deficiency of n-acetyltransferase-8) learning objective: explain the reason of increased toxicity of drugs biotransformed byacetylation.answer: disoniazid is biotransformed mainly by hepatic acetylation which is under genetic control. aboutone half of people of caucasian origin are slow acetylators, since they have an inheriteddeficiency of n-acetyltransferase. slow acetylators have a higher risk of isoniazid adverse effects.a) actually rifampin can increase, not reduce, the biotransformation of many drugs by increasingthe synthesis of microsomal enzymes.b, c, e) these pathological conditions do not cause peripheral neuropathy