A new drug was tested in an in vitro system. It was found that only one enantiomer of
the racemic pair bound substantially to a specific receptor, whereas the other enantiomer
showed a negligible binding. Which of the following terms best defines this property?
A. Intrinsic activity B. Affinity C. Stereo-selectivity D. Potency E. Variability F. Maximal efficacy
Stereo-selectivity-3) learning objective: define the term stereo-selectivityanswer: ca peculiar property of receptors is stereo-selectivity, that is often they bind only one enantiomerof a racemic pair.a) intrinsic activity refers to the ability of a drug (once bound to a receptor) to initiate changeswhich lead to a biological response.b) affinity refers to the tendency of a drug to bind to a receptor.d) potency refers to the dose of a drug required to produce a given effect.e) variability refers to the fact that the number of receptors can vary with time.f) maximal efficacy refers to the maximal effect that can be produced by a drug