The dominant follicle is a highly vascularized structure that, following ovulation, evolves into a highly vascularized corpus luteum . Which of the following growth factors is most likely involved with the process of luteal angiogenesis?
A. Placental growth factor (PGF) B. Insulin growth factor I (IGF1) C. Insulin growth factor II (IGF2) D. Epidermal growth factor (EGF) E. Vascular endothelial growth factor (VEGF)
Vascular endothelial growth factor (vegf)-vegf is an angiogenic growth factor secreted by the follicle just prior toovulation. vegf is required to form the dense capillary bed in the corpus luteum. the dense capillary bed provides thecorpus luteum with a high rate of blood flow, and this high rate of blood flow is second only to the brain (on a per gramtissue basis). this dense capillary bed also permits for the rapid secretion of progesterone into the maternal circulation.pgf is also an angiogenic growth factor, but is secreted after formation of the corpus luteum is complete. pgf acts inconcert with vegf to assist in the vascular remodeling of the uterine vessels and formation of the placental bloodvessels during early pregnancy.