A woman goes to her doctor for dysfunctional uterine bleeding. This woman has a high BMI, irregular menstrual cycles ranging from 21 to 65 days in length, and experiences heavy menstrual bleeding for 2 to 3 days during each menstrual period. This woman is afflicted with abnormally large amounts of acne, and has an unusually high degree
of facial hair. This woman suffers from unusually high levels of which hormone?
A. Progesterone B. Adolsterone C. Testosterone D. Cortisol E. Estrone
Testosterone-this woman is exhibiting a classic presentation of polycystic ovary syndrome(pcos), and this question tests your knowledge of the 2 cell theory of ovarian steroidogenesis. women with pcos typically exhibit elevated androgen levels, produced by the theca interna cells of the follicles. this excess androgen then exerts phenotypic changes associated with androgen action, such as increased facial hair. for reasons unknown, this overabundance of androgen is not aromatized into estradiol. a sufficient amount of androgen is aromatized, which leads to unopposed estradiol acting directly on the endometrium. the dysfunctional uterine bleeding is a direct effect of unopposed estradiol causing excessive endometrial proliferation. pcos will be covered in detail in semester 4.