Anticholinergics-tricyclic and monoamine oxidase (mao) inhibitor antidepressants have been found to be effective in treating clients with panic attacks. why these drugs help control panic attacks isnt clearly understood. anticholinergic agents, which are smooth-muscle relaxants, relieve physical symptoms of anxiety but dont relieve the anxiety itself. antipsychotic drugs are inappropriate because clients who experience panic attacks arent psychotic. mood stabilizers arent indicated because panic attacks are rarely associated with mood changes.