Testosterone is converted intracellarly by the 5 alphareductase enzyme to
dihydrotestosterone (DHT) in the prostate gland, sebaceous glands, hair follicles and testis. Changes in the localized
levels of DHT are associated with adverse prostate function, and elevated levels of DHT in hair follicles are associated
with male pattern baldness.
DHT and testosterone both bind to the androgen receptor. However, DHT exhibits a greater affinity for the androgen
receptor, and therefore able to exert heightened effects at lower concentrations.