A 65-year-old male was admitted to the emergency room and was diagnosed with a stroke. Appropriate drug treatment could be effective by which of the following means?
A. Raising the blood pressure B. Attempting to decrease disruption of the blood-brain barrier C. Reducing seizure activity in the cerebral cortex and limbic system D. Stabilizing body temperature E. Reducing brain serotonin levels in the brainstem and cerebral cortex
Attempting to decrease disruption of the blood-brain barrier -glutamate has been implicated in ischemia-induced brain damage following brain trauma such as a stroke. it has also been shown that administration of nmda-receptor antagonists following a stroke is effective in the treatment of stroke by reducing tissue infarction and neuronal cell death. the nmda-receptor antagonist is effective, in part, by decreasing disruption of the blood-brain barrier. it has been suggested that this becomes manifest by a blockade of the neuronal production of reactive oxygen species that occurs as a result of activation of nmda receptors. the other choices listed for the question have no known relationship to the process in question.