A pregnant mother has a routine ultrasound to determine the sex of her baby. The doctor informs her that the baby is anencephalic. Which of the following statements are most characteristic of anencephaly?
A. Results from failure of caudal neural tube closure B. Can often be treated successfully with surgery C. Associated with no change in alpha-fetoprotein D. Newborns with this condition may still display reflex activity E. Results from neural tube closure deficits in the second trimester