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Which of the following statements regarding the seronegative spondyloarthropathies is NOT true?



A. The most common extra-articular manifestation of ankylosing spondylitis is aortic root disease
B. There is a genetic component to theses arthropathies related to the HLA-B27 marker
C. Psoariatic arthropathy occurs in up to 20% of patients with psoriasis
D. In patients with IBD, the peripheral arthritis tends to correlate with flare-UPS of the bowel disease, but the spinal manifestations do not
E. Reactive arthritis (Reiter’s syndrome) develops 2-6 weeks after an episode of urethritis or dysentery
Asked by Aria, Last updated: Jul 02, 2020

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John Smith

John Smith

Answered Sep 08, 2016

The most common extra-articular manifestation of ankylosing spondylitis is aortic root disease-the seronegative spondyloarthropathies share the characteristics of sacroiliac involvement, peripheral inflammatory arthropathy, absence of rheumatoid factor, pathologic changes around the enthesis, and a genetic component related to the hla-b27. the most important of these include ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and the arthropathy of ibd. ankylosing spondylitis: back discomfort with radiologic evidence of sacroilitis, male predominance, uveitis is most common extra-articular manifestions, life-threatening aortic root disease rarely occursarthropathy of ibd: acute migratory, inflammatory polyarthritis of the peripheral joints (most commonly knees) in10-20% of patients with ibd. sacroilitis and spondylitis more common in males. the peripheral arthritis generally correlates with flare-ups of the bowel disease, but the spinal manifestations do not.psoriatic arthritis: 20% of patients with psoriasis. several forms (asymmetrical oligoarthropathy, symmetrical polyarthropathy, spondylitis, dip involvement, arthritis mutilans)reactive arthritis (reiters): asymmetric, polyarticular arthritis in a genetically susceptible host 2-6 weeks after an infection in the gu tract (chlamydia trahomatis) or gi tract (salmonella, shigella, yersinia, or campylobacter). single episode (mean length 4-7 months) or recurrent episodes of arthritis. antibiotics improve recovery time for patients with chlamydia-triggered reactive arthritis, but not with a gi cause.(chapter 114)
 

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