Which of the following statements regarding the prevention of breast cancer is true? A 52-year-old woman is worried about her risk of developing breast cancer. Her sister was recently diagnosed with breast cancer at the age of 45 years. Her mother also had breast cancer; the age at which her mother's breast cancer was diagnosed is unknown. The patient asks if there is anything she can do to reduce her risk of developing breast cancer.
A. No interventions have been shown to reduce the diagnosis of breast cancer B. A low-fat diet has clearly been shown to prevent breast cancer C. In women at high risk, treatment with tamoxifen significantly reduces the risk of developing breast cancer D. Raloxifene is more effective than tamoxifen in reducing the risk of developing breast cancer
In women at high risk, treatment with tamoxifen significantly reduces the risk of developing breast cancer-there has been much interest in the development of breast cancer prevention strategies. pharmacologic approaches are the most developed at this time. the nonsteroidal selective estrogen receptor modulator (serm) tamoxifen, a mainstay in the management of breast cancer, has also been tested as a chemopreventive agent. in a large united states trial, use of tamoxifen was associated with a reduction in the diagnosis of breast cancer of about 50%. on the basis of data from this trial, the food and drug administration approved the use of tamoxifen to reduce the occurrence of breast cancer in women at high risk, as defined by the eligibility requirements for this prevention trial. a meta-analysis demonstrated a 38% reduction in invasive breast cancer with tamoxifen. prevention strategies that involve alterations in lifestyle have been suggested. the womens health initiative did not show a clear advantage for a low-fat diet as a means of breast cancer prevention.