Which of the following statements concerning G6PD deficiency is the - ProProfs Discuss
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Which of the following statements concerning G6PD deficiency is the most accurate in the given-below case?
A 27-year-old African-American man with AIDS returns for a follow-up appointment. His CD4 count has dropped in recent months, and you plan to start dapsone for prophylaxis of Pneumocystis infection. Your patient denies any history of drug or food reactions, but you inform him that there is still some risk of hemolysis as a result of glucose-6-phosphate dehydrogenase (G6PD) deficiency.  



A. Less than 5% of black males in the United States are affected by G6PD deficiency.
B. The most common variant of G6PD is recognized by severe hemolysis early in life.
C. G6PD deficiency is a somatic gene mutation.
D. Because of the risk of oxidative stress associated with dapsone, it is important to screen users before starting the medication.
Asked by Dylan, Last updated: Dec 18, 2019

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John Smith

John Smith

Answered Sep 08, 2016

Because of the risk of oxidative stress associated with dapsone, it is important to screen users before starting the medication.-g6pd deficiency is one of the most common disorders in the world; approximately 10% of male blacks in the united states are affected, as are large numbers of black africans and some inhabitants of the mediterranean littoral. the gene for g6pd is on the x chromosome at band q28; males carry only one gene for this enzyme, so those males who are affected by the disorder are hemizygous. there are three clinical classes of g6pd deficiency: class i, which is the uncommon chronic congenital nonspherocytic hemolytic anemia; class ii, in which the enzyme deficiency is severe, but hemolysis tends to be episodic; and class iii, the most common variant, in which the enzyme deficiency is moderate and hemolysis is caused by oxidant attack. dapsone, which is capable of inducing oxidant-type hemolysis, has increasingly come into use as prophylaxis for pneumocystis jirovecii pneumonia in patients infected with hiv. therefore, it is important to screen potential users of dapsone for g6pd deficiency with the standard enzymatic tests.
 

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