Which of the following processes is most likely occurring in the hepatocytes described? A 40-year old man is brought to the emergency department after being involved in a motor vehicle collision. He is pronounced dead on arrival. He had a history of fever, headache, chills and pain in the upper right quadrant of the abdomen 5 days ago. During autopsy, histologic examination of a liver section shows disruption of the normal hepatic lobule. Small shrunken hepatocytes with intense eosinophilic cytoplasm, fragmented nuclear chromatin, and cytoplasmic bleb formations are noted.
A. Apoptosis B. Atrophy C. Caseous necrosis D. Coagulation necrosis E. Dysplasia F. Fatty change G. Heterophagy H. Liquefaction necrosis I. Metaplasia
There are some people, especially those who have not studied medicine who may not be familiar with the different ways that the cell can die. There are two ways. The first is Necrosis and the second one is Apoptosis which is option A in the choices. This is the right answer because through the autopsy, it is evident that cell death is evident.
There are some cell changes that have occurred even before the patient has died. Apoptosis is considered to be “programmed cell death.” This is because the cells die without outside forces. They just die on their own. As a result, there are some changes that may occur such as cell shrinkage, and all of the other signs that were pointed out.