Which components of the nephron would histologic examination of this patient's kidneys most likely show necrotic cells? A 25-year-old woman comes to the physician because of a 2-day history of decreasing urine output despite ample fluid intake. She underwent operative removal of a perforated appendix 3 weeks ago. She received intravenous gentamicin for 2 weeks. Physical examination shows no abnormalities.
A. Bowman capsule B. Collecting tubule C. Glomerular basement membrane D. Mesangium E. Proximal tubule
The correct answer is option E – Proximal tube This client is experiencing acute tubular necrosis caused by the use of aminoglycoside (Gentamicin). Aminoglycoside is known to be nephrotoxic, which can cause injury to the renal tubules, especially the proximal convoluted tubule and the thick ascending limb.
This leads to the death of tubular cells, which may be sloughed into the lumen and seen as brown cast. The Bowman capsule, collecting tubule, glomerular basement membrane, and the mesangium are less likely susceptible to other injury caused by toxic substances such as an aminoglycoside. I hope this helps!