A 42-year-old man comes to the physician because of a 4-week history of muscle cramping and pain. Two months ago, he began treatment with simvastatin (80 mg daily) for hypercholesterolemia. After 1 month, marked improvement was noted in his serum LDL-cholesterol concentration, but serum triglyceride concentration remained increased. At that time, gemfibrozil was added to his regimen to decrease his triglyceride concentration. Physical examination today shows no abnormalities. This patient’s myalgia is most likely related to which of the following effects of gemfibrozil on simvastatin?
A. Decreased bioavailability B. Increased absorption C. Inhibition of cytochrome P450 metabolism D. Inhibition of hepatic glycosylation E. Inhibition of hepatic sulfation