A 24-year-old woman with type I diabetes was brought unconscious to the emergency room. Her blood glucose level was 395 mg/dL. An intravenous infusion of insulin was started and the patient’s blood glucose decreased to a normal level after 6 hours. Which of the following molecular actions most likely contributed to the therapeutic effect of the drug in this patient?
A. Inhibition of glucose transporters in pancreas cell membranes B. Phosphorylation of tyrosine kinase receptors C. Activation of ATP-sensitive K+ channels in target cells D. Stimulation of hormone sensitive lipase E. Inhibition of liver glucokinase