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What is combination chemotherapy being considered?
Cisplatin is included in the regimen because of its effect on which of the following? A 25-year old man is diagnosed with advanced testicular cancer.



A. Dihydrofolate reductase
B. DNA
C. Microtubules
D. Purine ring biosynthesis
E. Ribonucleotide reductase

This question is part of NBME 13 Section 2 (50 questions)
Asked by Chachelly, Last updated: Apr 08, 2020

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2 Answers

C. Marcus

C. Marcus, Content Developer, Washington

Answered Oct 10, 2018

Chemotherapy is a common treatment for cancer patients. However, there is a drug that is used in chemotherapy that people may not be aware of. It is called Cisplatin. This helps with a bunch of different cancers including testicular, lung, bladder, breast, cervical and neuroblastoma, to name a few. Taking these drugs may treat or stop the cancer, but there are side effects to taking this drug including kidney damage and nerve damage.

One of the things that people are usually not aware of and it may sound strange is that this drug interferes with DNA. Its replication of DNA is what is affected and specifically includes the intrastrand cross-links and adducts. Another drug used is Oxaliplatin, but it is not used as much.

 

John Smith

John Smith

Answered Mar 18, 2017

DNA

Cisplatin crosslinks DNA in several different ways, interfering with cell division by mitosis. The damaged DNA elicits DNA repair mechanisms, which in turn activate apoptosis when repair proves impossible (from Wikipedia)
 

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