Which of the following is the most likely cause of this decrease? A - ProProfs Discuss
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Which of the following is the most likely cause of this decrease? A previously healthy 40-year old man is brought to the emergency department 1 hour after the onset of severe pain in his left leg while playing tennis. He is found to have ruptured the left Achilles tendon and undergoes operative repair and long leg cast immobilization. Six months later, the left calf shows a 2-cm decrease in circumference compared with the right calf.



A. Decreased glycogen synthesis
B. Decreased myosin light chain phosphatase activity
C. Increased phosphatidyl degradation
D. Increased protein degradation
E. Mitochondria damage
F. Necrosis of muscle fibers

This question is part of NBME 13 Section 2 (50 questions)
Asked by Chachelly, Last updated: Jun 29, 2020

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2 Answers

Barry Mclean

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Barry Mclean, Sales Manager, MBA, Ewa

Answered May 01, 2019

The correct answer is option D
The most likely cause of this man’s decrease in muscle size is the increase in protein degradation.

Muscle atrophy is when a muscle appears smaller than it used to be. It is the shrinkage of muscle fibers. It is mostly caused by lack of physical activity in that particular muscle.

During muscle atrophy, any proteolytic processes occur in the muscle. Most of the contractile proteins and organelles are removed from the affected muscle.
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John Smith

John Smith

Answered Feb 03, 2017

Increased protein degradation
 

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