Which of the following statements correctly pairs the system with the - ProProfs
     

Which of the following statements correctly pairs the system with the drug class that mainly affects it? CNS drugs often act on a specific neurotransmitter system.



A. Serotonergic system - Opioids
B. Cholinergic system - MAO inhibitors
C. Dopaminergic system - Phenothiazines
D. Noradrenergic system - Benzodiazepines
E. GABAergic system - Tricyclic antidepressants

This question is part of Pharm - Introduction to CNS Pharmacology

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1 Answer

John Smith

John Smith

Answered on Jan 27, 2017

Dopaminergic system - Phenothiazines

Answer: C (Katzung, pp 463, Brunton pp 462) Phenothiazines, butyrophenones as well as other neuroleptic drugs mainly interfere with the dopaminergic system by blocking dopaminergic receptors. This blockade seems to underlie both their clinical usefulness and their major adverse effects. A) Opioids act on the endorphinergic system. B, E) MAO inhibitors and tricyclic antidepressants mainly act on the noradrenergic and the serotonergic systems D) Benzodiazepines mainly act on the GABAergic system

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