Which of the following statements correctly pairs the system with the drug class that mainly affects it? CNS drugs often act on a specific neurotransmitter system.
A. Serotonergic system - Opioids B. Cholinergic system - MAO inhibitors C. Dopaminergic system - Phenothiazines D. Noradrenergic system - Benzodiazepines E. GABAergic system - Tricyclic antidepressants
(Katzung, pp 463, Brunton pp 462)
Phenothiazines, butyrophenones as well as other neuroleptic drugs mainly interfere with the
dopaminergic system by blocking dopaminergic receptors. This blockade seems to underlie
both their clinical usefulness and their major adverse effects.
A) Opioids act on the endorphinergic system.
B, E) MAO inhibitors and tricyclic antidepressants mainly act on the noradrenergic and the
D) Benzodiazepines mainly act on the GABAergic system