Which of the following mechanisms will lead to an increase in the collagen synthesis in this patient?
A 47-year-old woman comes to the physician because she wants to "do something about my wrinkles." Physical examination shows fine wrinkles in photodamaged skin on the face. Treatment with tretinoin is started.
A. Activation of nuclear gene transcription B. Decreased CAMP production C. Displaced vitamin A from cellular stores D. Increased sebum production E. Protection of keratinocytes from UVB irradiation
The correct answer to this question is A. Tretinoin is a prescription drug that is derived from vitamin A, and it is used to treat acne and damage to the skin. Improvements that patients experience include less acne, fewer fine lines, and less discoloration of the skin.
Tretinoin replaces old skin with new skin by increasing the growth rate of cells through the activation of nuclear gene transcription. Tretinoin most often comes in the form of a topical cream. Common side effects include skin irritation, sore throat, stinging at the application site, and discoloration of the skin.