What is the most likely outcome of this patient's deficiency, at the level of gene expression? A 3 y.o. patient with delayed mental acuity is shown to have an enzyme deficiency of Histone Acetyltransferase (HAT) activity.Â
A. Ubiquitination of histones H3 and H4 and increased overall transcription B. Fragmentation of poorly protected chromosomal DNA and reduced transcription C. Activation of histone H3 and H4 gene expression D. Reduced transcription rates because nucleosomes occupy promoters E. Uncoupling of transcription and translation in neurons
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A. Lucius, Senior Content writer, Diploma in Literature, Dover, Delaware
Answered Nov 01, 2019
The correct answer to this question is option D – Reduced transcription rates because nucleosomes occupy promoters. Histone acetyltransferase, commonly known as HATs, are enzymes that acetylate histones on DNA. HATs work by transferring acetyl group lysine amino acid that is present of histone. Acetylation of histones on DNA usually causes gene expressions as this allows transcription factors to bind easily to regulatory sites such as promoter regions on the DNA.
In this child, Histone acetyltransferase is deficient. This makes histone remain tightly bound to DNA, and the nucleosome (DNA with histone) remains unchanged, making it impossible for regulatory sites to be occupied by transcription factors. This will ultimately lead to a reduced rate of transcription.