Which of the following presence in the biopsy specimen most clearly suggests diffuse alveolar damage rather than bronchiolitis obliterans-organizing pneumonia in this patient?
A previously healthy 25-year-old man is admitted to the hospital for treatment of viral pneumonia. He is mechanically ventilated because of respiratory failure due to hypoxemia. An open-lung biopsy specimen is obtained and shows a pattern of acute lung injury.
A. Alveolar hyaline membrane B. Foamy macrophages C. Interstitial collagen deposition D. Masson bodies E. Uniform fibroblastic proliferation
The correct answer to this question is A, Alveolar Hyaline Membrane. This is a pattern, which appears in lung disease. Alveolar Hyaline Membranes can be found in various illnesses such as ARDS, which is acute respiratory distress syndrome, and TRALI, which stands for transfusion related acute lung injury.
These illnesses are mainly found in adults, but it can also be found in newborns. Alveolar Hyaline Membranes can be found by conducting a biopsy and will appear as glassy pink. The membranes will line the alveolar walls and are caused by the necrotic debris of cells, as well as the fibrinous exudate.