What is the action of glucocorticoids in asthma? - ProProfs Discuss
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What is the action of glucocorticoids in asthma?



A. Decrease the formation of cytokines, in particular the Th2 cytokines and decrease eosinophilic recruitment and activation
B. Decrease IgE production and IgE receptor expression and inhibit vasodilatation by suppressing PGE2 and PGI2 though induction of COX-2
C. Decrease spasmogens LTC4 and LTD4, decrease chemotactins LTB4 and platelet activating factor and therefore decreasing recruitment and activation of inflam cells
D. Can upregulate B2 adrenoceptors and decrease mediator release from eosinophils
E. Long term Rx reduces the early phase response to allergens and prevents exercise-induced asthma

This question is part of respiratory pharmacology
Asked by Maddi, Last updated: Dec 05, 2017

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1 Answer

John Smith

John Smith

Answered on Dec 26, 2016

Decrease the formation of cytokines, in particular the Th2 cytokines and decrease eosinophilic recruitment and activation
Decrease IgE production and IgE receptor expression and inhibit vasodilatation by suppressing PGE2 and PGI2 though induction of COX-2
Decrease spasmogens LTC4 and LTD4, decrease chemotactins LTB4 and platelet activating factor and therefore decreasing recruitment and activation of inflam cells
Can upregulate B2 adrenoceptors and decrease mediator release from eosinophils
Long term Rx reduces the early phase response to allergens and prevents exercise-induced asthma
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