If in case you are not too familiar with what these two are, Jawbone 2 and Jawbone Prime are Bluetooth headsets. The Jawbone Prime is considered to be an upgrade of the Jawbone 2.
The noise cancellation of the Jawbone 2 works well but if you want something that will cancel noise better, the Jawbone Prime will definitely offer something more.
There are also some additional features that you can expect from the Jawbone Prime such as the AVAD also known as Acoustic Voice Activity Detection. This will definitely enhance your listening experience. The fit of the Jawbone Prime on the ears is also considered better.