Which of the following best explains the longevity of the herpes simplex virus? A 36-year-old man comes to the physician for a routine examination. He has a 5-year history of recurrent episodes of genital herpes treated with acyclovir. He says, "I`ve been taking the medication, but I still occasionally get lesions. When will I be cured?" The physician informs him that herpes simplex is a lifelong infection, with no cure at the present time.
A. Continual replication in dendrite cells B. Continual replication in epithelial cells of the skin C. Continual replication in sacral root ganglia D. Continual replication in T lymphocytes E. Establishment of latent infection in B lymphocytes F. Establishment of latent infection in circulating immune cells G. Establishment of latent infection in epithelial cells of the skin H. Establishment of a latent infection in sensory nerve cells