Which of the following best explains the longevity of the herpes - ProProfs Discuss
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Which of the following best explains the longevity of the herpes simplex virus? A 36-year-old man comes to the physician for a routine examination. He has a 5-year history of recurrent episodes of genital herpes treated with acyclovir. He says, "I`ve been taking the medication, but I still occasionally get lesions. When will I be cured?" The physician informs him that herpes simplex is a lifelong infection, with no cure at the present time.



A. Continual replication in dendrite cells
B. Continual replication in epithelial cells of the skin
C. Continual replication in sacral root ganglia
D. Continual replication in T lymphocytes
E. Establishment of latent infection in B lymphocytes
F. Establishment of latent infection in circulating immune cells
G. Establishment of latent infection in epithelial cells of the skin
H. Establishment of a latent infection in sensory nerve cells

This question is part of NBME 13 section 1 (qst 1-50)
Asked by Wyatt Williams on Nov 18, 2016

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2 Answers

John Adney

John Adney

Answered on Mar 15, 2017

John is Right. C is wrong. H is correct. "Continual replication" does not explain "longevity." Recall that replication only occur during reactivation.
 Reply

John Smith

John Smith

Answered on Nov 18, 2016

Establishment of a latent infection in sensory nerve cells
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