The dominant follicle is likely selected during the preceding menstrual cycle, and then grows prolifically during the proliferative phase of the next cycle. You want to administer a receptor antagonist designed to block growth of the dominant follicle. Inhibition of which receptor would most likely result in suppressed growth and development of the dominant follicle?
A. Gonadotropin releasing hormone receptor B. Luteinizing hormone receptor C. Follicle stimulating hormone receptor D. Estrogen receptor E. Progesterone receptor
Blocking the GnRH receptor will result in decreased production of LH and FSH,
which will subsequently inhibit growth of the dominant follicle.
Interestingly, you could also suppress follicle growth and development by administering receptor antagonists designed
to inhibit FSH receptor pathway or the LH receptor pathway, but the best answer is a GnRH antagonist that blocks both
LH and FSH activity. Recall the 2cell theory of steroidogenesis, and how LH and FSH action on the theca and granulosa
cells is a complementary system that results in estradiol production.