Which of the following statements regarding CNS drug action on - ProProfs
     

Which of the following statements regarding CNS drug action on synaptic potentials are correct?



A. A drug-induced EPSP usually makes the membrane potential less negative
B. An IPSP may be produced by drugs that cause opening of Cl- channels
C. An IPSP may be produced by drugs that cause opening of K+ channels
D. Most CNS drugs affect synaptic potential by activating or inhibiting NA+/K+ ATPase
E. All drug-induced EPSP and IPSP are very short-lasting potentials (less than 5 milliseconds)

This question is part of Pharm - Introduction to CNS Pharmacology

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Chachelly

Chachelly

Answered on Apr 27, 2019

A drug-induced EPSP usually makes the membrane potential less negative
An IPSP may be produced by drugs that cause opening of Cl- channels
An IPSP may be produced by drugs that cause opening of K+ channels

Answer: ABC (Katzung, pp 340, Golan pp 94) By definition an excitatory post synaptic potential (EPSP) occurs when the membrane potential of the postsynaptic cell becomes less negative (depolarization) so making the neuron in an excited state (action potential generation is facilitated). Conversely an inhibitory postsynaptic potential occurs when the membrane potential of the postsynaptic cell becomes more negative. (hyperpolarization). This can happen either by increasing the negative charges inside the cell (when Cl- channels open, Cl- enters the cell since the concentration of Cl- outside is higher than the concentration inside) or by decreasing the positive charges inside the cell (when K+ channels open, K+ exits the cell since the concentration of K+ inside is higher than the concentration outside ). D) CNS drugs do not act on NA+/K+ ATPase. Actually this enzyme is very seldom a drug target. A notable exception are cardiac glycosides, whose mechanism of action involves a specific blockade of the enzyme. E) EPSP and IPSP can be either fast (few milliseconds) or slow (few seconds).

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