Which activity will be inhibited when the following patient is given appropriate pharmacotherapy?
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A previously healthy 32-year-old man is brought to the emergency department because of a 1-day history of intermittent flashing spots and blurred vision, vomiting, confusion, and difficulty walking. He is a painter and says that yesterday he cleaned up a spilled bottle of paint thinner. Ophthalmologic examination shows dilated pupils with hyperemia of the optic disc and retinal edema. Physical examination shows tachypnea. Serum studies show an anion gap metabolic acidosis.
A. Alcohol dehydrogenase B. Aldehyde dehydrogenase C. Formaldehyde dehydrogenase D. Lactate dehydrogenase E. Pyruvate dehydrogenase
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Answered on Feb 26, 2019
The correct answer to this question is A. Alcohol dehydrogenase is a group of dehydrogenase enzymes, a class of zinc enzymes, that catalyze the oxidation of primary and secondary alcohols and facilitate the interconversion of alcohols and aldehydes with the reduction of hydride anion to NAD+ to NADH, the realease of a proton.
Alcohol dehydrogenase will be inhibited because it is the first step in the metabolism of both methanol and ethylene glycol. The patient has tachypea which is abnormally rapid breathing. The patient also has anion gap metabolic acidosis which is the result of type I diabetes, chronic alcoholism, or undernutrition.