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Which of the following labeled response has the highest amount of calcium sequestration in sarcoplasmic reticulum?

Which of the following labeled response has the highest amount of calcium sequestration in sarcoplasmic reticulum?

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The tracing shows contractile responses of a skeletal muscle preparation to electrical stimulation at five different frequencies.

A. A
B. B
C. C
D. D
E. E

This question is part of NBME 13 Section 2 (50 questions)
Asked by Chachelly, Last updated: Oct 17, 2018

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5 Answers

Marwan

Marwan

Answered on Mar 11, 2019

I think the answer is A.
Ca sequestration means getting it back into the sarcoplasmic reticulum. The lower the frequency of stimulation, the more relaxation is possible and the more sequestration would take place during relaxation phases between the contractions. In E, the stimuli are very frequently applied, we havesustained contraction/tetanus, meaning that intracytoplasmic calcium will remain high to cater for the constant demand and not be sequestered back into the sarcoplasmic reticulum since there's no relaxation happening.

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H. Jones

H. JonesWeb Content Writer, San Antonio,
Web Content Writer, San Antonio,

Answered on Sep 20, 2018

The answer to this is A. You can see the amount of calcium based on how low the stimulus frequency is. If you would check the given figure, the lowest point of stimulus frequency is A which means that this is the answer. Stimulus frequency refers to the amount or the rate that the stimulus is applied to the market.

Sequestration occurs when there is no blood in some spaces of the body wherein blood or other body fluids are expected. This can lead to various health complications and it should be addressed immediately. Sequestration may have a different meaning when used in chemistry.

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Nefertiti

Nefertiti

Answered on Mar 31, 2017

It's not E. I put E and missed it. The answer is A.
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John Adney

John Adney

Answered on Feb 18, 2017

Amount of calcium sequestered in the sarcoplasmic reticulum is highestduring relaxation, i.e. when not contracting. Thus it is highest when the stimulus frequency is lowest -> Answer A.
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John Smith

John Smith

Answered on Nov 06, 2016

E
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