Which DDI may be a cause for concern and therefore, should be - ProProfs Discuss
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Which DDI may be a cause for concern and therefore, should be addressed with the physician?

This question is part of Ischemic Heart Disease/Chronic Stable Angina
Asked by ToeKneeAy, Last updated: Mar 18, 2020

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ToeKneeAy

ToeKneeAy

Answered Oct 27, 2018

Simvastatin 40mg and amlodipine
Simvastatin 20mg and diltiazem
Simvastatin 40mg and diltiazem

Concomitant use of simvastatin no greater than 20mg is recommended with amlodipine. Concomitant use of simvastatin no greater than 10mg is recommended with non-dihydropyridine calcium channel blockers. Using more than this amount can increase the risk of rhabdomyolysis and other muscle toxicities.
 

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