Which of the following types of modification is required prior to the destruction of misfolded proteins in this patient’s proteasomes? A 29-month old boy is brought to the physician by his mother because of a 2-week history of green nasal discharge and cough. He has a past history of frequent respiratory tract illnesses and pneumonia. The mother states that her son has a 6-month history of large, foul-smelling stools and a salty taste when she kisses him. There is no family history of a similar condition. He is at the 5th percentile for height and below the 3rd percentile for weight. His temperature is 38.3C (100.9F). Abdominal examination shows distention. Genetic testing shows a mutation in the Phe residue at position 508 in the cystic fibrosis transmembrane conductance regulator gene.
A. Dimerization B. Glycosylation C. Phosphorylation D. Sulfation E. Ubiquitination