A client with carcinoma of the lung develops the syndrome of inappropriate antidiuretic hormone (SIADH) as a complication of the cancer. The nurse anticipates that which of the following may be prescribed? Select all that apply.
A. Radiation B. Chemotherapy C. Increased fluid intake D. Serum sodium blood levels E. Decreased oral sodium intake F. Medication that is antagonistic to antidiuretic hormone (ADH)
Radiation Chemotherapy Serum sodium blood levels Medication that is antagonistic to antidiuretic hormone (ADH)
Cancer is a common cause of SIADH. In clients with SIADH. excessive amounts of water are reabsorbed by the kidney and put into the systemic circulation. The increased water causes hyponatremia (decreased serum sodium levels) and some degree of fluid retention. SIADH is managed by treating the condition and its cause. and treatment usually includes fluid restriction. increased sodium intake. and a medication with a mechanism of action that is antagonistic to ADH. Sodium levels are monitored closely. because hypernatremia can suddenly develop as a result of treatment. The immediate institution of appropriate cancer therapy (usually either radiation or chemotherapy) can cause tumor regression so that ADH synthesis and release processes return to normal.