Which of the following events is the most likely cause of the increased muscle weakness in this patient?
A 31-year old woman is brought to the emergency department by her husband because of difficulty breathing and severe muscle weakness for 10 minutes. She has a 3-year history of myasthenia gravis treated with neostigmine. The husband reports that she doubled her dosage 2 days ago because she was feeling extraordinarily weak, but her weakness has increased since then.
A. Autoimmune hyperactivation of nicotinic receptors B. Autoimmune inactivation of muscarinic receptors C. Desensitization of nicotinic receptors D. Hypersensitization of muscarinic receptors E. Insufficient release of acetylcholine