A. Objective signs of CNS dysfunction, seizures, paralysis and altered conciousness ( inflammation of the brain) B. Slow but progressive and persistant viral infection of the CNS with severe and irreversable damage C. Both meningitis and encephaltis manifestations. D. Selective destruction of the anterior horn motor cell , spinal cord and or brain , complete paralysis of muscles. Occasionally respiratory insufficient , associated with meningitis E. Meningeal inflammation, increase in lymphacytes, mononuclear cells in CSF, absence of bacteria and fungi. Fever, headache, stiff neck, nausea, vommitting, irratiblity, conciousness is in tact.