Which of the following is the most appropriate loading dose of this drug for this patient (in mg)?
A 76-year-old man is admitted to the hospital because of a 2-week history of a persistent urinary tract infection. He is 165 cm (5 ft 5 in) and weighs 55 kg (121 lb); BMI is 20 kg/m2. The physician plans to initiate treatment. A component of the initial treatment includes an intravenous bolus dose of an antibiotic to attain an initial peak serum concentration of 8 mg/L. The volume of distribution of the antibiotic is 0.35 L/kg. Laboratory studies show a 24hour urine creatinine clearance within the reference range.
If a man comes to the hospital because he has been suffering from a urinary tract infection for a couple of weeks, he will most likely be admitted to the hospital. This is because the problem has continued for an extended, and he is an older person. The young and older adults are usually more of a risk when it comes to health problems due to their age and vulnerability.
The doctor may plan on doing an initiate treatment. To do this treatment, the doctor must supply a medication which would be an intravenous bolus dose of an antibiotic. This is used to attain an initial peak serum concentration of eight milligrams per L. The most appropriate treatment would be 150 milligrams.