Which of the following mechanisms is the most likely cause of this patient’s condition? A 4-year-old girl has had “puffy" eyes for the past 3 days. She has had an upper respiratory tract infection for the past week. A urine dipstick test shows 3+protein. Urinalysis shows no red or white blood cells or casts.
A. Attack by antiglomerular basement membrane antibodies B. Damage to the loop of Henle C. Damage to the proximal renal tubule D. Loss of negative glomerular charge E. Presence of a posterior urethral valve